Coadministration of pexidartinib (a CYP3A4 inducer) with delicate CYP3A substrates may result in critical therapeutic failures. If concomitant use is unavoidable, boost the CYP3A substrate dosage in accordance with authorized products labeling.
Prolonged use during pregnancy may end up in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and needs management As outlined by protocols formulated by neonatology gurus
apalutamide will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs which can be CYP3A4 substrates may lead to decrease exposure to those medications.
fentanyl, promethazine. Either improves toxicity from the other by pharmacodynamic synergism. Modify Therapy/Check Carefully. Coadministration of fentanyl with anticholinergics could enhance risk for urinary retention and/or severe constipation, which may result in paralytic ileus.
Check Intently (1)omaveloxolone will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Patients with major chronic obstructive pulmonary illness or cor pulmonale, and those with a substantially reduced respiratory reserve, hypoxia, hypercapnia, or pre-current respiratory depression are at amplified risk of diminished respiratory drive like apnea, even at proposed dosages
buprenorphine transdermal and fentanyl both of those improve sedation. Prevent or Use Alternate Drug. Restrict use to patients for whom alternative treatment options are inadequate
differs appreciably from other mu opioids, partially because the research methods that might potentially make this differentiation (e.
Check Closely (one)mitotane will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to your lower in fentanyl plasma concentrations, lack of efficacy or, possibly, enhancement of the withdrawal syndrome in the affected person who has formulated Bodily dependence to fentanyl.
rifampin will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to a lessen in fentanyl plasma concentrations, insufficient efficacy or, perhaps, enhancement of a withdrawal syndrome in a patient who may have designed physical dependence to fentanyl.
pentazocine decreases effects of fentanyl by pharmacodynamic antagonism. Steer clear of or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may well lower fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.
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After halting a CYP3A4 inducer, given that the effects of the inducer drop, the fentanyl plasma concentration will increase which could increase or prolong both the therapeutic and adverse effects.
fentanyl and fentanyl intranasal both of those enhance sedation. Stay away from or Use Alternate Drug. Restrict use fentanyl anesthésie to patients for whom alternate treatment options are inadequate